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The Nature Miracle in Treatment of Hemorrhoids Rectol®
(Myrtol 5%)
The Nature Miracle in Treatment of Hemorrhoids:
1. Immediate relief of pain
2. Immediate and complete improvement of disease
3. Easy and hygienic use for patient
4. Optimized and controlled administration
History: As an herbal medicine, Rectol® is astringent, anti-inflammatory, local anesthetic and antifungal obtained from Myrtle (Myrtus communis). Dioscorides (3rd century B.C.) has introduced myrtle as a medicinal plant in his book. In most references of traditional medicine, common properties for myrtle has been indicated such as antiseptic, astringent, anti-inflammatory, anti-hemorrhoid and etc. Avicenna, Abu-Reyhan Birouni, Rhezus, Aghili Khorasani, Jorjani, Abu-Mansour Al-Heravi and famous scientists of other countries had been believed in various medicinal properties of myrtle, especially anti-hemorrhoid action.
Pharmacological effects: These are evidences that prove myrtle is effective on hemorrhoids:
In references, medicinal properties of myrtle have been related to its essential oil extracted from the leaves called Myrtol which has the following actions:
1- Effects on microorganisms: In addition to traditional medicine which has introduced myrtle as antiseptic and antiparasitic, there are research articles published in valid references that have been showed the effects of myrtol on microorganisms (fungi and bacteria). Myrtol has strong inhibitory action on bacteria (all gram-positives and most gram-negatives) and fungi including saprophytes, pathogens and especially Candida albicans.The effect of myrtol on the treatment of Candidiosis is unique.
2- Anti-inflammatory effects: In traditional medicine, myrtle has been introduced as an effective plant on the treatment of itching and inflammation after insect bite. Recent studies have been showed that the anti-inflammatory effect of myrtol is due to 5-Lipoxygenase inhibition.
3- Antidecongestant effects: In traditional medicine and today, the essential oil from myrtle is used for relief of respiratory congestion as an inhalation. Now it has been proved that the major components of myrtol including α-pinene and 1,8-cineole have vasoconstriction activity which explains this property.
4- Anti-itching and analgesic effects: Generally, essential oils have local anesthetic action which is due to rapid absorption from skin or mucus and effect on myelin of neurons. So, myrtol as an essential oil has this common property and is effective on itching and pain when administered locally.
Basic studies: Analysis of myrtol essential oil was carried out with Gas chromatography & Mass spectrometry. Concentrations of the major components of the essential oil have been given in the Table 1:
|
Trace
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1-p-menthen-
8-yl-acetate
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Linalyl acetate
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1,8-cineole
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d-limonene
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p-cymene
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α-pinene
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Name
|
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4%
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2.31%
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5.76%
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30.41%
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15.90%
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1.34%
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39.59%
|
%
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Table 1
Pathological studies: After 72-hour exposure of rectum mucosal cells to Rectol®, no side effect was detected. Skin exposure to Rectol® was not showed any allergic reactions.
Toxicological studies: Oral administration of myrtol (1-2 mL/day) in human has not resulted in any adverse effect.
Clinical trials: Administration of Rectol® in 40 patients suffering from hemorrhoids in comparison with Antihemorrhoid® revealed significant statically difference for the benefit of Rectol®. The symptoms of disease including pain, bleeding, itching and inflammation were decreased according to Table 2:
|
Improvement
after Rectol®
administration
Symptoms
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Weak
(No significant
improvement)
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Moderate
(Improvement of less than 50%))
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Good
(Improvement of more than 50%)
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Excellent
(Complete improvement & decrease of degree of disease)
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Itching
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0
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15%
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30%
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55%
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Bleeding
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0
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5%
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55%
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40%
|
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Inflammation
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0
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0
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65%
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35%
|
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Pain
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0
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0
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55%
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45%
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Table 2
In this clinical study, the patients treated with Rectol® and physicians conducting the study questioned the effectiveness of medication. The results are seen in Table 3:
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Satisfaction of treatment
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Dissatisfaction
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Relative
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Complete
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Physicians
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5%
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35%
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60%
|
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Patients
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5%
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35%
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60%
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Table 3
It can be observed that in most cases, the patients and physicians consistently rated the effectiveness of Rectol® in decreasing of pain, inflammation and itching as good and excellent. In addition to alleviation of symptoms, also improvement and decrease of degrees of disease has been obtained.
Especial packaging: In order to easy, hygienic and also optimized and controlled administration of medication, Rectol® package has 8 rectal disposable applicators. Because of the especial designation of applicators, the medication will be offloaded in a controlled and tedious manner only in the rectum region. With every applicator, there is a 7×7 cm cotton gauze used for placing on the anus after administration of the medication in order to prevent of underwear contamination with probable exudates.
Dosage forming: In each rectal administration, 2.5 g of ointment will be offloaded with applicator.
Caution: It is recommended that before first rectal administration, a little amount of ointment would be rubbed on the skin of the arm or behind the ear. If any allergic reaction be observed, the medication should not be used.
Dose: It should be used every 12 hours, if the physician has not been mentioned any other instruction.
Administration: At first, pull out the piston (Fig. 1), then fill out the cylinder with ointment (Fig. 2) and again place the piston into cylinder (Fig. 3). Insert the nozzle into anus cautiously until the ballets prevent more insertion (Fig. 4). Push the piston slowly down into cylinder until all the ointment be offloaded into rectum completely (Fig. 5). After pulling out the applicator from the anus, place the cotton gauze on the anus (Fig. 6). Throw the applicator away in the bin (Fig. 7).
References:
1 -Agro,s Dictionary of Medicinal Plants. p.222.
2 -Antibacterial and Antifungal Survey in Plants used in Indigenous Herbal- Medicine of South East Regions of Iran. Journal of biological sciences, 4(3) : 405-412, 2004.
3 -Antifungal Activity of the Essential Oil of Myrtus Communis Var.microphylla Herba Hungarica, tom. 27. no 2-3, 1988.
4 -Antimicrobial Activity of Certain Plants Used in Turkish Traditional Medicine. Asian journal of plants sciences, 3(1) : 104-107, 2004.
5 -Anti Yeast Activity of Some Plants Used in Traditional Herbal – medicine of Iran. Journal of biological sciences, 4(2) : 212-215, 2004.
6- British Pharmacopoeia. V(4), p.A323 - A334, 2003.
7 -Dictionary of Natural Products. V(4) M-Q, Chapman& Haff, p.4085, 1994.
8- Davis Patricia Aromatherapy AN A-Z. p.232-233.
9- Harrison,s Principles of Internal Medicine. (16th Edition), McGraw-Hill,Medical Publishing Division. p.1801-1802.
10- Mosby,s Handbook of Herbs &Natural Supplements, Linda Skidmore-Roth, RN, MSN, NP. p.612.
11- Herbal Medicine Handbook. p.312-313.
12- Indian Materia Medica. p.838-839.
13- Handbook of Medicinal Herbs, Jemes A.Duke. (2th Edition), p. 519-520, 2002.
14 -Klaassen C.D.,Watkins JB.Casarett & Doull’s Toxicology ., The Basic Science of Poisons. Companion Handbook, Fifth Edition , Pergamon Press , New York. P.169-174
15 -Martindale The complete drug reference. V(1), p.1243, 2005.
16- Martindale The complete drug reference. V(2), p.1804, 2005.
17- Interference of Myrtol Standardized With Inflammatory and Allergic Mediators. 48(11), p.985-989, 1998.
18- A Handbook of Medicinal Plants, Prajapati, N. D.; Purohit, S. S. & …, Agrobios (India ). p.357.
19- Schwart’s Principles of Surgery. (8th Edition), McGraw-Hill,Medical Publishing Division. p.1101-1104.
20- The Greek Herbal of Dioscorides.
21- Toxicology Oral Toxicity of Essential Oil of Myrtle & Adaptive Liver Stimulation.12, p.335-342, 1979.
22- Trease & Evans Pharmacognosy, Evans, W. C. (15th Edition), W.B. SAUNDERS. p.477, 2002.
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